Doctorado en Ciencias Biomédicas (DBC)

A continuación, se nombran las tres LGAC que conforman el plan de estudios del programa de estudios del doctorado:

1. Enfermedades secundarias a la inflamación y al daño oxidativo: cardiovascular; enfermedad hepática crónica, cirrosis, fibrosis pulmonar, enfermedades neurodegenerativas, cáncer y enfermedades autoinmunes.

2. Enfermedades del crecimiento, endocrinológicas y nutricionales. Síndrome metabólico, crecimiento intrauterino retardado, diabetes y sus complicaciones (renales, cardiovasculares, oftalmológicas, etc.), diabetes gestacional, obesidad, ovario poliquístico.
3. Innovación de técnicas, validación de dispositivos biomédicos, biosimilares y aplicaciones bioinformáticas, biofísicas y nanomedicina.

Productividad académica relevante del programa de posgrado.

Puche JE, Muñoz Ú, García-Magariño M, Sádaba MC, Castilla-Cortázar I.Partial IGF-1 deficiency induces brain oxidative damage and edema, which are ameliorated by replacement therapy. Biofactors. 2016 Jan-Feb; 42(1):60-79.

Lara-Diaz VJ., Castilla-Cortázar, Martín-Estal I, García-Magariño M, Aguirre GA, Puche JE, Sádaba MC, de la Garza RG, Morales LA and Muñoz U. IGF-1 deficiency alters “per se” gene expression of proteins involved in inflammation, cytoskeleton and liver architecture. J Biochem and Physiol 2016 (in press).

García Varela R, Ramírez OR, Serna Saldivar SO, Altamirano J, Cardineau GA., Cancer cell specific cytotoxic effect of Rhoeo discolor extracts and solvent fractions. Journal of Ethnopharmacology, Vol.190, Pag.4658, 2016 Revistas Arbitradas.

Anti-Cancer Activity of Maize Bioactive Peptides. Díaz-Gómez JL, Castorena-Torres F, Preciado-Ortiz RE, García-Lara S. Front Chem. 2017 Jun 21;5:44. 

Martínez LM, Videa M, López Silva T, Castro S, Caballero A, Lara-Díaz VJ, Castorena-Torres F. Two-phase amorphous-amorphous solid drug dispersion with enhanced stability, solubility and bioavailability resulting from ultrasonic dispersion of an immiscible system. Eur J Pharm Biopharm. 2017 Oct;119:243-252.

Ayleen Salazar Cantú, Perla Pérez Treviño, Dolores Montalvo Parra, Jaime Balderas Villalobos, Norma. L. Gómez Víquez, Noemí García and Julio Altamirano, Role of SERCA and the Sarcoplasmic Reticulum Calcium Content on Calcium Waves Propagation in Rat Ventricular Myocytes. ISSN: 00039861, Archives of Biochemistry and Biophysics, Vol.604, Pag.1119, 2016; Revistas Arbitradas.

Martinez HR, Escamilla-Ocañas C, González-Garza MT, Moreno-Cuevas J. Clinical and MRI tongue abnormalities in amyotrophic lateral sclerosis patients. Neurologia, Vol.31, Pag.0-0, 2016; Revistas Indizadas.

Martínez HR, Escamilla Ocañas CE, Tenorio-Pedraza JM, Gómez-Almaguer D, Jaime- Perez JC, Olguín-Ramírez LA, Sergio Salazar-Marioni S, González-Garza MT. Altered CSF cytokine network in Amyotrophic Lateral Sclerosis patients: A pathway-based statistical analysis. Cytotherapy, Vol.90, Pag.1-5, 2016; Revistas Indizadas.

Marisela Martinez-Gamboa, Delia Elba Cruz-Vega, Jorge Moreno Cuevas, Maria Teresa Gonzalez-Garza, Induction of nestin early expression as a hallmark for mesenchymal stem cells expression of PDX-1 as a pre-disposing factor for their conversion into insulin producing cells. 2005-5447, International Journal of Stem Cells, Vol.9, Pag.0-0, 2016.

Duval F, Cruz-Vega DE, Gónzalez-Gamboa I, González-Garza MT, Ponz F, Sánchez F, Alarcon-Galvan G, E Moreno-Cuevas JE. Detection of autoantibodies to vascular endothelial growth factor receptor-3 in bile duct ligated rats and correlations with a panel of traditional markers of liver diseases. Disease Markers.doi: 10.1155/2016/6597970 ISSN: 0278-0240, Disease Markers, Vol.2016, Pag.0-0, 2016; Revistas Indizadas.

Chaikriangkrai K, Jyothula S, Jhun HY, Estep J, Loebe M, Scheinin S, Torre-Amione G., J Impact of pre-operative coronary artery disease on cardiovascular events following lung transplantation., Heart Lung Transplant Heart Lung Transplant, Vol. , Pag.115-121,2016; Revistas Indizadas.

Gupte AA, Cordero-Reyes AM, Youker KA, Matsunami RK, Engler DA, Li S, Loebe M, Ashrith G, Torre-Amione G, Hamilton DJ.Differential Mitochondrial Function in Remodeled Right and Nonremodeled Left Ventricles in Pulmonary Hypertension., Journal Card Failure, Vol. , Pag.73-81, 2016; Revistas Indizadas .

Cotter G, Davison BA, Milo O, Bourge RC, Cleland JG, Jondeau G, Krum H, O'Connor CM, Metra M, Parker JD, Torre-Amione G, van Veldhuisen DJ, Kobrin I, Rainisio M, Senger S, Edwards C, McMurray JJ, Teerlink JR; VERITAS Investigators. Predictors and Associations With Outcomes of Length of Hospital Stay in Patients With Acute Heart Failure: Results From VERITAS., J Card Failure, Vol. , Pag.815-822, 2016.

Yue X, Lin X, Yang T, Yang X, Yi X, Jiang X, Li X, Li T, Guo J, Dai Y, Shi J, Wei L, Youker KA, Torre-Amione G, Yu Y, Andrade KC, Chang J., Rnd3/RhoE Modulates Hypoxia- Inducible Factor 1¿/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia- Inducible Factor 1 and Regulates Responsive Cardiac Angiogenesis., Hypertension, Vol. Pag.597-605, 2016.

Alvarez P, Cordero-Reyes AM, Uribe C, De Hoyos P, Martinez D, Bhimaraj A, Trachtenberg BH, Ashrith G, Torre-Amione G, Loebe M, Amione-Guerra J, Rice L, Estep JD., Acquired and Hereditary Hypercoagulable States in Patients with Continuous Flow Left Ventricular Assist Devices: Prevalence and Thrombotic Complications J Card Failure, Vol. Pag.501-511, 2016.

Hamilton DJ, Zhang A, Li S, Cao TN, Smith JA, Vedula I, Cordero-Reyes AM, Youker KA, Torre-Amione G, Gupte AA., Combination of angiotensin II and l-NG-nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure., Am J Physiol Heart Circ Physiol, Vol. Pag.310-316, 2016; Revistas Indizadas.

Rios-Ibarra CP, Rodriguez-Silva CJ, López-Chuken YA, Ortiz-Lopez R, Fernandez- Castillo E, Del Toro Runzer CB, Armenta-Perez VP, Flores-Gutierrez JP, Quintanilla- Guzman A, Salinas-Santander M, Gonzalez-Guerrero JF, Bosques-Padilla F, Santos A, Martinez-Rodriguez HG.TS-VNTR genotype in mexican colon cancer patients treated with 5-fluouracil. The Official Journal of Balkan Union of Oncology, 2016; 21(4): 935- 940.

Corona-Meraz FI, Navarro-Hernández RE, Ruíz-Quezada SL, Madrigal-Ruíz PM, Castro- Albarrán J, Chavarría-Ávila E,Guzmán-Ornelas MO, Gómez-Bañuelos E, Petri MH, Ramírez-Cedano JI,Aguilar-Aldrete ME, Ríos-Ibarra C, Vázquez-Del Mercado M. Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance. Mediators Inflamm. 2016; 2016:3085390.

Gómez Macías GS, Pérez Saucedo JE, Cardona Huerta S, Garza Montemayor M, Villarreal Garza. C, García Hernández I INVASIVE LOBULAR CARCINOMA OF THE BREAST WITH EXTRACELLULAR MUCIN: A CASE REPORT, Int J Surg Case Rep, Vol.3, Pag.33-36, 2016.

Villarreal-Garza C, Bargallo-Rocha JE, Soto-Perez-de-Celis E, Lasa-Gonsebatt F, Arce- Salinas C, Lara-Medina F, Reynoso-Noverón N, Matus-Santos J, Cabrera P, Alvarado-Miranda A, Mohar A., REAL-WORLD OUTCOMES IN YOUNG WOMEN WITH BREAST CANCER TREATED WITH NEOADJUVANT CHEMOTHERAPY, Breast Cancer Res Treat, Vol.157, Pag.385-394, 2016.

De Ita JR, Castilla-Cortázar I, Aguirre GA, Sánchez-Yago C, Santos-Ruiz MO, Guerra-Menéndez L, Martín-Estal I, García-Magariño M, Lara-Díaz VJ, Puche JE, Muñoz U. J Altered liver expression of genes involved in lipid and glucose metabolism in mice with partial IGF-1 deficiency: an experimental approach to metabolic syndrome. Transl Med. 2015 Oct 14;13:326.

Castilla-Cortázar I, Gago A, Muñoz Ú, Ávila-Gallego E, Guerra-Menéndez L, Sádaba MC, García-Magariño M, Olleros Santos-Ruiz M, Aguirre GA, Puche JE. Mechanisms Underlying Testicular Damage and Dysfunction in Mice With Partial IGF-1 Deficiency and the Effectiveness of IGF-1 Replacement Therapy. Urology. 2015 Dec;86(6):1241-9

Castilla-Cortázar I, Rodríguez De Ita J, Martín-Estal I, Castorena F, Aguirre GA, García de la Garza R, Elizondo MI. Clinical and Molecular Diagnosis of a Cartilage-Hair Hypoplasia with IGF-1 Deficiency. Am J Medical Genetics 2016.

Castilla-Cortázar I, De Ita, JR, Aguirre GA, Castorena-Torres F, Ortiz-Urbina J, García- Magariño M,de la Garza RG, Diaz Olachea C, Elizondo Leal MI. Fanconi Anemia associated to Laron Syndrome? Am J Medical Sciences 2016 (in press).

Castilla-Cortazar I, De Ita JR, García–Magariño M, de la Garza RG, Aguirre GA, Lara- Diaz VJ, Elizondo, MI. Primary Growth Hormone Insensitivity (Laron’s Syndrome): Mexican case report. Endocrinology, Diabetes and Metabolism Case Reports 2016 (submitted).

Elizondo-Montemayor L, Silva-Platas C, Torres-Quintanilla A, Rodríguez-López C, Ruiz-Esparza GU, Reyes-Mendoza E, Garcia-Rivas G. Association of Irisin Plasma Levels with Anthropometric Parameters in Children with Underweight, Normal Weight, Overweight, and Obesity. Biomed Res Int. 2017;2017.

Elizondo-Montemayor L, Hernández-Escobar C, Lara-Torre E, Nieblas B, Gómez-Carmona M. Gynecologic and Obstetric Consequences of Obesity in Adolescent Girls. J Pediatr Adolesc Gynecol. 2017 Apr;30(2):156-168.

Elizondo-Montemayor L, Hernández-Brenes C, Ramos-Parra PA, Moreno-Sánchez D, Nieblas B, Rosas-Pérez AM, Lamadrid-Zertuche AC.High hydrostatic pressure processing reduces the glycemic index of fresh mango puree in healthy subjects. Food Funct. 2015 Apr;6(4):1352-60.

Ludwig KU, Ahmed ST, Böhmer AC, Sangani NB, Varghese S, Klamt J, Schuenke H, Gültepe P, Hofmann A, Rubini M, Aldhorae KA, Steegers Theunissen RP, Rojas Martinez A, Reiter R, Borck G, Knapp M, Nakatomi M, Graf D, Mangold E, Peters H.Meta-analysis Reveals Genome Wide Significance at 15q13 for Nonsyndromic Clefting of Both the Lip and the Palate, and Functional Analyses Implicate GREM1 as a Plausible Causative Gene. PLoS Genetics, Vol.12, Pag: e1005914. 2016.

Bryan Marrugo OL, ArellanosSoto D, Rojas Martinez, A, Barrera Saldaña H, Ramos Jimenez J, Vidaltamayo R, Rivas Estilla AM., The anti dengue virus properties of statins may be associated with alterations in the cellular antiviral profile expression. ISSN: 17912997. doi: 10.3892/mmr.2016.5519., Molecular Medicine Reports, Vol.14, Pag.21552163, Revistas Indizadas, 2016.

Vázquez Martínez OT, González Betancourt A, Barboza Cerda MC, González González SE, Lugo Trampe Á, Welsh O, Rojas Martínez A, Martínez Rodríguez H G, Ocampo Candiani J, OrtizLópez R.,Human papillomavirus type 2 associated with pyogenic granuloma in patients without clinical evidence of warts. ISSN: 13654632. doi: 10.1111/ijd.12982., International Journal of Dermatology, Vol.55, Pag. :745-50, 2016.

Perez Maya AA, Hinojosa Robles RM, Barcenas Walls JR, Rojas Martinez A, Barrera Saldaña HA,Ortiz Lopez R. Draft Genome Sequence of an Atypical Strain of Streptococcus pneumoniae Serotype 19A Isolated from Cerebrospinal Fluid. Genome Announcements, Vol.4, Pag. e00277-16, 2016.

Lavariega JC, Garza R, Gómez LG, Lara-Diaz VJ, Silva-Cavazos MJ. An Electronic Health Record for Pediatricians: Adoption barriers, services, and use in Mexico. ISSN: 1555-3396; eISSN 1555-340X DOI: 10.4018/IJHISI.2016070104, International Journal of Healthcare Information Systems and Informatics, Vol.11, Pag.57-69.

Jorge E Valdez-García, Julio C Hernandez-Camarena, Juan F Lozano-Ramírez, Judith Zavala, Denise Loya-García, Jesús Merayo-Lloves. Correlation of age, corneal curvature and spherical equivalent with central corneal thickness, Revista Mexicana de Oftalmología, Vol. Pag.0-0, 2016.

Soriano Hernández AD, Montes Galindo DA, Ceja Espíritu G, Guzman Esquivel J, Rodríguez Sánchez IP, Newton Sánchez OA, Martinez Fierro ML, Briseño Gómez XG, Rojas Martínez A, Delgado Enciso A., Galván Salazar HR, Preclinical trial on the use of doxycycline for the treatment of adenocarcinoma of the duodenum. ISSN: 20499450. Molecular and Clinical Oncology, Vol.5, Pag.657659, 2016.

Ruiz-Esparza GU, Segura-Ibarra V, Cordero-Reyes, A M Youker, K A Serda, R E, Cruz-Solbes, A. S., Amione-Guerra, J., Yokoi, K., Kirui, D. K., Cara, F. E., Paez- Mayorga, J., Flores-Arredondo, J. H., Guerrero-Beltrán, C. E., Garcia-Rivas, G., Ferrari, M., Blanco, E. and Torre-Amione G. A specifically designed nanoconstruct associates, internalizes, traffics in cardiovascular cells, and accumulates in failing myocardium: a new strategy for heart failure diagnostics and therapeutics, Eur J Heart Fail, Vol.18, Pag.169- 178, 2016.

Silva-Platas C, Guerrero-Beltrán CE, Carrancá M, Castillo EC, Bernal-Ramírez J, Oropeza Almazán Y, González LN, Rojo R, Martínez LE, Valiente-Banuet J, Ruiz-Azuara l, Bravo-Gómez ME, García N, Carvajal K, García-Rivas G, Antineoplastic copper coordinated complexes (Casiopeinas) uncouple oxidative phosphorylation and induce mitochondrial permeability transition in cardiac mitochondria and cardiomyocytes, J Bioenerg Biomem, Vol.48, Pag.43-54, 2016.

Sánchez-Trujillo L, Vázquez-Garza E, Castillo EC, García-Rivas G, Torre-Amione G., The role of adaptive immunity in the development and progression of heart failure: new evidences, Arch. Med. Res, Vol. Pag.0-0, 2016.

Hernandez-Trejo M, Garcia-Rivas G, Torres-Quintanilla A, Laresgoiti-Servitje E, Relationship between Irisin Concentration and Serum Cytokines in Mother and Newborn., PLoS One., Vol.11, Pag.1-13, 2016.

Martínez HR, González-Garza MT, Moreno- Cuevas J, Escamilla Ocañas CE, Tenorio- Pedraza JM, Hernández-Torre M, Long-term survival in amyotrophic lateral sclerosis after stem cell transplantation into the frontal motor cortex. ISSN: 1465-3249, Cytotherapy, Vol.18, Pag.806-808, 2016.

Jorge E Valdez-García; Guillermo Mendoza; Judith Zavala; Angel Zavala-Pompa; Gabriela Brito; Jorge A Cortés-Ramírez; Jennifer, In Vivo Biocompatibility of Chitosan and Collagen¿vitrigel Membranes for Corneal Scaffolding: A Comparative Analysis, Elisseeff, Current Tissue Engineering, Vol.5, Pag.123-129, 2016.

Gomez-Rueda H, Palacios-Corona R, Gutiérrez-Hermosillo H, Trevino V,A robust biomarker of differential correlations improves the diagnosis of cytologically indeterminate thyroid cancers, International Journal of Molecular Medicine, Vol., Pag.0-0, 2016.

Gutiérrez-Monreal MA, Treviño V, Moreno-Cuevas JE, Scott SP. Identification of circadian-related gene expression profiles in entrained breast cancer cell lines, , Chronobiology International, Vol. Pag.0-0, 2016.

Trevino V, Cassese A, Nagy Z, Zhuang X, Herbert J, Antzack P, Clarke K, Davies N, Rahman A, Campbell MJ, Guindani M, Bicknell R, Vannucci M, Falciani F.,A Network Biology Approach Identifies Molecular Cross-Talk between Normal Prostate Epithelial and Prostate Carcinoma Cells, PLOS Computational Biology, Vol. Pag.0-0, 2016.

Ruiz-Esparza GU, Segura-Ibarra V, Cordero-Reyes AM, Youker KA, Serda RE, Cruz- Solbes AS, Amione-Guerra J, Yokoi K, Kirui DK, Cara FE, Paez-Mayorga J, Flores- Arredondo JH, Guerrero-Beltrán CE, Garcia-Rivas G, Ferrari M, Blanco E, Torre-Amione GA. Specifically designed nanoconstruct associates, internalizes, traffics in cardiovascular cells, and accumulates in failing myocardium: a new strategy for heart failure diagnostics and therapeutics., Eur J Heart Fail., Vol. , Pag.167-169, 2016.

   Internas     

• Hospital San José